2C-B

A series of 2,5-dimethoxyphenethylamines, collectively referred to as 2Cs, have psychoactive effects. The most effective 2C compounds are substituted at the 4 position of the aromatic ring; many are scheduled as illegal substances. 2C-B is described formally as 4-bromo-2,5-dimethoxy phenethylamine. This hallucinogenic designer drug activates the serotonin receptor 5-HT_2C (pEC₅₀ = 6.8 for arachidonic acid release). Its metabolism has been reviewed. LC-MS/MS screening methods for identifying this compound in serum have been developed. 2C-B is regulated as a Schedule I compound in the United States. This product is intended for forensic and research purposes.

WARNING This product is not for human or veterinary use.

About 2C-B Chemical

2C-B (4-bromo-2,5-dimethoxyphenethylamine), also known as Nexus, is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug. The substance was first synthesized by Alexander Shulgin in 1974, and gained an initial reputation for potential psychotherapeutic use, but its use has been limited to mainly recreational use. To date, there is limited scientific information regarding the drug’s pharmacokinetics and pharmacological effects in humans. The existing studies primarily classify 2C-B as a stimulant and hallucinogen, and less commonly an entactogen and empathogen.

2C-B, also referred to by a number of slang names, is known to circulate in the illicit market in multiple forms: as a powder, in capsules or pills. For recreational use, the substance is generally consumed orally or nasally. In Shulgin’s book PiHKAL, the oral dosage range is listed as 12–24 mg.

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